Trastuzumab (Herceptin®)
HER2-targeted monoclonal antibody · IV infusion (440mg vial) · Administered in clinic · HCPCS J9355
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Your Cost / Cycle
Notes
Manufacturer Patient Assistance (Genentech ONESource) BEST
For patients meeting income criteria Income-based
$0
Full drug cost covered for qualifying patients. Enrollment lag: 2–4 weeks. Apply before starting treatment.
340B Program
If your center is a 340B-covered entity
~$420
25–50% below commercial price. Only available at qualifying entities. UCLA and Cedars-Sinai are 340B-covered.
Medicare Part B (Physician-administered)
Covered under Part B, not Part D — no donut hole
~$680
20% coinsurance after Part B deductible. Medigap plan F/G covers the 20% copay.
Commercial PPO (Blue Shield, in-network)
Specialty tier · Prior authorization required PA Required
~$1,240
Specialty tier copay after deductible. After OOP max is met: $0. Average time to OOP max for HER2+ patients: 3–4 months.
Genentech Oncology Together Copay Card
For commercially insured patients only — not for government plans
~$5/cycle
Reduces commercial copay to as low as $5/cycle. Cannot be used with Medicare or Medicaid. Maximum $25,000/year.
Subcutaneous Biosimilar (Trastuzumab-dkst / Ogivri)
FDA-approved biosimilar · 30–40% lower cost than reference product
~$780
Ask your oncologist if biosimilar substitution is appropriate for your regimen. Clinically equivalent for most HER2+ indications.
Uninsured / Self-pay (gross charge)
Hospital charge master rate — ask about financial assistance before paying this
~$6,800/cycle
Gross charge master price. Almost no uninsured patient should pay this rate. Ask about financial assistance, PAP enrollment, or 340B access before any infusion.
$81,000+
Potential annual savings versus self-pay if you qualify for manufacturer assistance or are treated at a 340B-covered center. An Arca navigator can confirm your eligibility before your first treatment.
Financial Assistance & Copay Support Programs
Genentech ONESource PAP
Income-based. For uninsured or underinsured patients. Drug provided at no cost. Apply before starting treatment.
Apply at gene.com →Genentech Oncology Together
Copay assistance for commercially insured patients. Not for government insurance. Up to $25,000/year.
Learn more →PAN Foundation — Breast Cancer Fund
Premium and copay assistance for insured patients with financial need. Fund opens periodically — check for open enrollment.
panfoundation.org →CancerCare Co-Pay Assistance
Provides co-payment assistance for cancer-related treatment costs. Disease-specific eligibility.
cancercare.org →
Data sources: Drug pricing sourced from CMS Part B drug payment allowances (ASP + 6%), GoodRx, Cost Plus Drugs, HRSA 340B entity database, and manufacturer PAP program eligibility criteria. Last updated Q1 2025. Prices vary by location, dosing schedule, and individual plan. Verify all costs with your oncology team and insurance plan before treatment begins.